By P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)
P. Denoix and G. Mathe nearly 70% of melanoma sufferers relapse after surgical procedure earlier than the fifth 12 months and, more often than not, for instance in breast carcinoma, they relapse nonetheless later as much as the 20 th yr. For a few enormous time, the tactic of melanoma remedy has been constrained to the sophistication of surgery-radiotherapy combos that maximally diminished the occurrence of neighborhood and local relapses in websites that have been inside of their succeed in. this present day, the perform of medical oncology is unthinkable with out the lively participation of the scientific oncologist. he's the "third guy" of the medical oncology workforce, and he has lately targeted realization at the proven fact that so much relapses come up from far-off metastases end result of the proliferation of cells seeded there after having left the first tumor website on the time of operation and, accordingly, are inaccessible to any shape oflocal and/or nearby therapy. in this facts, scientific oncologists have proposed the applying of scientific remedies for disseminated minimum residual disorder (MRD). they've got on hand capability: chemother apy and immunotherapy. clinical oncologists usually will be divided into 3 teams: chemotherapists, immunotherapists, and chemoimmunotherapists. The natural chemotherapists, who had already cured a few malignant neoplasias reminiscent of Hodgkin's ailment, acute lymphoid leukemia, placental choriocarcinoma, and Wilms' tumor, suggestion they may have the technique of attacking the residual disorder of universal cancers.
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Extra info for Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I: Markers and General Problems of Cancer Adjuvant Therapies
54, 797-802 (1970) 11. Tatarinov, Y. : Presence of embryo specific a globulin in the serum of patients with primary hepatocellular carciBoma. Vol. Med. Khim. 10, 90-95 (1964) Casein and Breast Cancer! J. C. Hendrick, P. F. Zangerle, and P. Franchimont The proteins of skim milk may be divided into two categories: 1. The milk-specific proteins, which predominate; 2. The proteins of plasma origin. Caseins are the main components in the protein group of plasma origin. 4 g per 100 ml of mature milk.
Development of a bioassay for human putative lymphoma stem cells. Blood (1979) (in press) 6. : Tumor size, sensitivity to therapy and design of treatment schedules. Cancer Treatment Rep. 61, 1307 (1977) 7. , Ansfield, F. : Adjuvant chemotherapy-radiotherapy in breast carcinoma. In: Adjuvant therapy of cancer. , Jones, S. ), pp. 165-170. Elsevier, North-Holland 1977 8. Salmon, S. , Hamburger, A. : Quantitation of differential sensitivity of human-tumor stem cells to anticancer drugs. New Engl.
I' •• • •• ••• •• •• • • • • •••• I l-m) • •• •• • ....... • Undetectable 171 151 Fig. 3. Casein levels in patients with various malignancies FI SRI. FIBRI. 0 FIBRI. E 20 o ~ x ml . ~---:rrr + 10 IT IT O~--------------~----------------J-----------------~ 1 10 100 1000 ng / tube Fig. 4. Displacement curves using K-casein (I + II, II, III + IV), intact fibrinogen, and fragments D and E of fibrinogen 42 J. C. Hendrick et aI. 40 -o! oc- -. l< 20 I- 0 .. 2 Non neoplastIc disease 237 Cancer at the onset of the clinical course 194 I 3 I Lung cancer Digestive cancer at the onset at the onset of the clinical of the cl i nical course course 64 27 Breast cancer at the onset of the clinical course 39 Fig.
Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I: Markers and General Problems of Cancer Adjuvant Therapies by P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)