Get Analytical Profiles of Drug Substances and Excipients, Vol. PDF

By Harry G. Brittain

ISBN-10: 0122608283

ISBN-13: 9780122608285

Even if the legit compendia outline a drug substance through its id, purity, energy, and caliber, they as a rule don't offer different actual or chemical facts, nor do they record tools of synthesis or pathways of actual or organic degradation and metabolism. Such details is scattered in the course of the medical literature and the documents of pharmaceutical laboratories.Edited via the affiliate Director of Analytical study and improvement for the yankee organization of Pharmaceutical Scientists, Analytical Profiles of Drug components and Excipients brings this data jointly in a single resource. The scope of the sequence has lately been multiplied to incorporate profiles of excipient fabrics.

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2 Water Content The water content of citric acid is tested according to USP [46] general test <92 1>, Method I. 8% for the hydrate form. 3 Readily Carbonizable Substances Any carbonizable material present in a sample of citric acid is examined by the following procedure [46]. O g sample of powdered acid is transferred to a 22 x 175-mm test tube, previously rinsed with 10 mL of sulfuric acid TS and allowed to drain for 10 minutes. 10 mL of sulfuric acid TS is added, and the mixture is agitated until dissolution is complete.

O g sample of powdered acid is transferred to a 22 x 175-mm test tube, previously rinsed with 10 mL of sulfuric acid TS and allowed to drain for 10 minutes. 10 mL of sulfuric acid TS is added, and the mixture is agitated until dissolution is complete. 5 minutes, and the level of the acid solution s kept below the level of the water during the entire period. Then thc tube is cooled in running water, and the acid solution is transferred to a color comparison tube. ). Following the directions of general test 6 3 1>.

And citric acids in cranberry juice cocktail and apple juice by two reverse phase liquid chromatography columns in tandem [55]. ), and a computing integrator (Hewlett-Packard Integrator 3390 [replaced by No. 3396B], or equivalent). 6 mm} in tandem with and followed by a Waters Radial-Pak C 18 cartridge { 5 pm particle size, I0 cm long} used with a Radial Compression Module. 8 mL/min. An assay for citric acid in an irrigation solution composed of citric acid, magnesium oxide, and sodium carbonate is mentioned in USP 24 [46].

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Analytical Profiles of Drug Substances and Excipients, Vol. 28 by Harry G. Brittain


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